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RELA Break Apart FISH Probe

Empire Genomics’ RELA Break Apart FISH Probe is designed to flank the RELA gene and is typically used for detecting RELA rearrangements such as translocations. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The probe comes labeled in green and orange by default, but may be customized to meet your needs.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping
Download Datasheet Download FISH Protocol Download Material Safety Data Sheet

SKU Test Kits Buffer Dye Color Order Now
RELABA-20-GROR  (Standard Design) 20 (40 μL) 200 μL
RELABA-20-AQOR 20 (40 μL) 200 μL
RELABA-20-GOGR 20 (40 μL) 200 μL
RELABA-20-GORE 20 (40 μL) 200 μL
RELABA-20-GRGO 20 (40 μL) 200 μL
RELABA-20-GRRE 20 (40 μL) 200 μL
RELABA-20-ORGR 20 (40 μL) 200 μL
RELABA-20-REGO 20 (40 μL) 200 μL
RELABA-20-REGR 20 (40 μL) 200 μL

Gene Summary

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Gene Details

Gene Symbol: RELA

Gene Name: RELA Proto-oncogene, NF-kB Subunit

Chromosome: CHR11: 65421066-65430443

Locus: 11q13.1

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging

Ependymoma is a tumor of the central nervous system that can exhibit fusion of the RELA gene. Diagnosing these accurately is important, and can be done with FISH, IHC, or DNA methylation. FISH analysis was performed with RELA break apart probes (RP11_58D3 and RP11_436C17/RP11_1104L6). An MN1 and YAP1 break apart probe were also used in conjunction with the DNA methylation.
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Product Details

Product: RELA FISH Probe

Test Kits: 20 (40 μL)

ISH Buffer: 200 μL

SKU: RELA-20-OR

Material Safety Data Sheet: MSDS.pdf

Turnaround Time: 7-10 Business Days

Shipping Time: 1-2 Day Expedited Shipping